RNA as a Drug Target

The Next Frontier for Medicinal Chemistry

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Beschreibung

<p><b>Discover a new paradigm in drug discovery that greatly expands the space of addressable drug targets and potential novel drugs</b></p> <p>Existing paradigms for drug discovery have focused largely on enzymes and other proteins as drug targets. In recent years, however, different varieties of ribonucleic acids have emerged as a viable focus for target-based drug discovery, with the potential to revolutionize the strategy and approach for this essential step in the drug development process.</p> <p><i>RNA as a Drug Target: The Next Frontier for Medicinal Chemistry </i>offers a practice-oriented introduction to developing drug-like small molecules that selectively modulate both coding and non-coding RNAs. Beginning with a description and characterization of existing druggable RNAs, the book discusses how to approach different RNA targets for drug discovery. The result is a crucial resource for targeting RNAs and creating the next generation of life-saving pharmaceuticals.</p> <p><i>RNA as a Drug Target </i>readers will also find:</p> <ul> <li>A complete "toolbox" for working with RNA, from structure determination to screening and lead generation techniques</li> <li>A wide range of addressable targets and mechanisms, including splicing modulation, riboswitches, targeted degradation, and more</li> <li>Authoritative discussion of the potential of RNA-targeted small molecule therapeutics for drugging the epitranscriptome</li> </ul> <p><i>RNA as a Drug Target</i> provides an expert introduction to a new frontier in pharmaceutical research for medicinal chemists, biochemists, molecular biologists, and members of the pharmaceutical industry.</p>

Artikeldetails

EAN

9783527351008

Sprache

Englisch

Einband / Art

Buch

Maße

245 x 171 x 25 mm

Erscheinungsjahr

2024

Verlag / Hersteller

Wiley-VCH GmbH