Solid-State Materials in Pharmaceutical Chemistry

Properties, Characterization, and Applications

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Beschreibung

<p><b>Updated and expanded information on the properties of pharmaceutical solids and their impact on drug product performance, quality, and stability</b></p><p><i>Solid-State Materials in Pharmaceutical Chemistry</i> provides readers with a comprehensive and up-to-date resource for understanding and controlling the solid-state properties of pharmaceutical materials, enabling the development of safe and effective medicines including small molecule compounds, peptides, proteins, and nucleotides. This new edition covers the significant transformations in the landscape of pharmaceutical research, development, and manufacturing since the previous edition was published, presenting both novel challenges and unprecedented opportunities.</p><p>New chapters in this edition cover physical and chemical properties of RNA therapeutics, a frontier to many life-saving medicines and vaccines including Covid vaccines, and final stage drug substance manufacturing and control, addressing challenges in API process development including impurity purging, chiral separation, final form preparation, particle size reduction, and nitrosamine control. Readers will also find other updated topics including bulk and surface properties of solids, lipid nanoparticles, applications of pharmaceutical solvates in impurity purging and final form preparation, pharmaceutical cocrystal engineering to enable chiral separation, the emerging technique of microcrystal electron diffraction in solid form characterization, poor wettability of APIs, oral delivery of peptides such as semaglutide, injectable drug-device combination products, and N-nitrosamine control in drug product.</p><p>This updated and revised Second Edition still features:</p><ul><li>Physical and chemical properties of solid-state pharmaceuticals such as amorphous forms, mesophases, polymorphs, hydrates/solvates, salts, co-crystals, nano-particles, and solid dispersions</li><li>Characterization techniques for solid form identification and phy

Artikeldetails

EAN

9781394254446

Sprache

Englisch

Einband / Art

Buch

Maße

288 x 233 x 36 mm

Erscheinungsjahr

2026

Verlag / Hersteller

John Wiley & Sons Inc