Late-Stage Functionalization and Diversification in Organic Synthesis

Methods and Applications

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Beschreibung

<p><b>Presents state-of-the-art strategies for the late-stage functionalization and diversity-oriented synthesis of challenging organic compounds</b></p><p>Late-stage functionalization (LSF) and diversity-oriented synthesis have emerged as powerful approaches in contemporary organic chemistry, enabling the selective modification of complex molecules at advanced stages of synthesis. These strategies offer unique advantages in drug discovery, medicinal chemistry, and natural product derivatization, where access to structurally diverse analogues is crucial. By allowing transformations that would otherwise require lengthy synthetic routes, LSF and diversity-oriented synthesis open pathways to molecules of high biological, pharmaceutical, and material relevance, significantly streamlining discovery processes.</p><p><i>Late-Stage Functionalization and Diversification in Organic Synthesis: Methods and Applications</i> provides a comprehensive overview of the latest developments in this rapidly expanding field. Presenting both practical methodologies and mechanistic insights, the book covers transition metal catalysis, photo- and electrocatalysis, flow chemistry, and radioisotope insertion. In addition, the book:</p><ul><li>Places a unique focus on diversity-oriented synthesis, showcasing C-O, C-N, and C-S bond activation</li><li>Highlights molecular editing and stereochemical editing as powerful new strategies for structural diversification</li><li>Includes applications to natural products, pharmaceuticals, and radiopharmaceuticals</li></ul> <p><i>Late-Stage Functionalization and Diversification in Organic Synthesis: Methods and Applications</i> is essential reading for graduate students, postdoctoral researchers, and professionals in organic chemistry, medicinal chemistry, and natural products research. It is particularly suited for advanced courses in organic synthesis and catalysis, and also serves as a practical reference for chemists working in the pharmaceutical and

Artikeldetails

EAN

9783527354184

Sprache

Englisch

Einband / Art

Buch

Maße

248 x 173 x 24 mm

Erscheinungsjahr

2026

Verlag / Hersteller

Wiley-VCH GmbH